Research Progress in the Relationship between Cancer Stem Cellsand Cellular Senescence

CSCs (cancer stem cells) are a subset of cancer cells that are carcinogenicity, self-renewal andcan produce. The abnormal differentiation and unlimited proliferation of CSCs play an extremely important rolein the occurrence and development of tumors, and the abnormal differentiation of CSCs can even promote cancerrecurrence. At present, an increasing number of studies have shown a close relationship between CSCs and senescence. Senescence cancer cells can transdifferentiate into CSCs, which can also undergo senescence changes. Thesesenescence CSCs are closely related to the occurrence and development of tumors and play an important role intumor recurrence and metastasis. This article provides a review on the characteristics of CSCs, the relationship between CSCs and cellular senescence, and the research on the senescence regulation mechanism of CSCs, providingnew ideas for exploring new methods of tumor treatment from the perspective of senescence in clinical practice.

CSTR: 32200.14.cjcb.2023.11.0016