Research Progress on the Relationship between Mast Cellsand Cardiovascular Disease
DU Yanhuan1,2, ZHANG Shizhong1,2*
As immune cells of the bone marrow lineage, mast cells are widely distributed in mucous membranes and connective tissues. Receptors on mast cells binding to their ligands, regulate the activation of mast cellsand release a variety of active mediators with biological effects, thereby enable mast cells to participate in physiological and pathological processes such as immune defense, thrombosis, damage repair and myocardial remodeling. In recent years, the role and pathogenic mechanisms of mast cells in cardiovascular diseases have become newresearch hotspots. Research on cardiovascular related diseases targeting mast cells and their mediators has enteredthe clinical trial stage. This article mainly reviews the role of mast cells in cardiovascular diseases and their potential clinical application value, with a view to providing new ideas for the treatment of cardiovascular diseases.
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