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The Expression of DC-SIGN in Human Renal Tissue with Nephropathy and on Renal Tubular Epithelial Cells
Tong Zhou*, Yu-Mei Zhang, Xiao Li, Kai-Yin Wu, Jie Zou, Qiao-Li Gu1, Yan-Yun Zhang1,Dong-Qing Zhang1, Nan Chen
Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;1Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract: DC-specific ICAM-grabbing non-integrin (DC-SIGN， CD209)， the pattern recognition receptor and adhesion receptor of dendritic cell (DC)， belongs to C-type lectin and plays an important role in DC migration and adhesion， inflammatory response， activating naïve T cells， initiating immune response and immune escape of pathogens and tumors. In this study， we observed the expression and distribution of DC-SIGN and DC-SIGN+ DC in renal tissue with nephropathy， and the presence of DC-SIGN on cultured human renal tubular epithelial cells under inflammatory condition. The expression of DC-SIGN was up-regulated in tubular epithelial cells from the early stage of nephritis on， which extent was increased consistent with the progression of nephropathy (P<0.01) and correlated tightly with the degree of tubular interstitial fibrosis (P<0.01). In vitro， the expression of DC-SIGN on cultured human renal tubular epithelial cells was elevated in the presence of TNF-α. In addition， DC-SIGN+ DC was distributed mainly among renal interstitial area， which increased significantly with the progression of nephropathy (P<0.01) and correlated with degree of renal tubularinterstitial fibrosis (P<0.01) and the extent of DC-SIGN (P<0.01). The number of DC-SIGN+ DC was associated markedly with renal function (P<0.05). DC-SIGN may mediate DC on the renal tubular interstitial injury induced by an immuno-inflammatory response.
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