Interaction of Formononetin on Autophagy, Inflammation and Oxidative Stress after Cerebral Stroke

Formononectin is widely present in clover and Chinese medicine Astragalus membranaceus, and is a major member of the isoflavone family. It has antioxidant, anti-infection, anti-apoptosis, improving blood circulation and other pharmacological effects, and has great potential in the prevention and treatment of nervous system disease such as cerebral stroke. With the increasing incidence of cerebral stroke year by year, it will be of great significance to study the protective effects of natural Chinese herbal medicine on nerve injury after cerebral stroke. This article focuses on the effects of formononetin on autophagy, inflammation and oxidative stress of nerve cells after stroke, and discusses the correlation among the three mechanisms of action, providing new reference for basic research and clinical treatment of cerebral stroke.

CSTR: 32200.14.cjcb.2023.10.0014