Research Progress on the Role of the DCBLD2 in Diseases
LIU Yanjie, LI Shenjun, WANG Xiaotong, WANG Zhen, DU Yayue, WU Rina, NIU Honglin*
DCBLD2 (discoidin, CUB, and LCCL domain-containing protein 2) is a member of DCBLD receptor family. It is highly conserved among vertebrates. Studies have found that it has participated in regulating various physiological processes, including cell proliferation, migration and signal transduction. Most current research on DCBLD2 focuses on both cardiovascular disease and cancer, while there are few studies on diabetic nephropathy or immunological disease. This review mainly describes the structure, functions of DCBLD2 as well as its pathophysiological roles and mechanisms in cardiovascular disease and cancer. Also, the important roles of DCBLD2 in diabetic nephropathy and immune diseases are also briefly summarized, which provides a reference for further studies on DCBLD2 in clinical diseases.
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