Home > Browse Issues > Vol.45 No.10
Research Progress of Nucleolar Stress
WU Jiafa, PAN Lin, NIU Mingfu*
(National Experimental Teaching Demonstration Center for Food Processing and Safety, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China)
Abstract:
Nucleolar stress refers to the abnormality of nucleolar structure and function caused by a variety of cell injuries, which ultimately leads to the activation of P53 or other stress signaling pathways and changes in cell behavior. As a cellular stress sensor, the nucleolus plays a central role in the cellular stress response network, and abnormal nucleolar function is associated with various diseases such as tumor and neurodegenerative diseases. This article reviews the advances in the research on the inducers, characteristics, signaling pathways, biological functions of nucleolar stress and its relationship with human diseases.
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