The Role of Exosomes in Musculoskeletal Degenerative Disease
LIU Yandong1#, ZHANG Yanjun2#, DENG Qiang2*, LI Zhongfeng2, PENG Randong2
In recent years, exosomes have attracted widespread attention due to their physiological and pathological effects in various diseases and enhancing tissue repair function. In the musculoskeletal system, exosomes carrying a variety of bioactive molecules have multiple sources such as osteoblasts, osteoclasts, muscle cells and bone marrow mesenchymal stem cells. They can participate in many physiological and pathological processes of the musculoskeletal system (sarcopenia, osteoporosis, osteosarcopenia) by coordinating the communication between different cells. These functions are finally reflected in participating in muscle repair and bone remodeling. Exosomes, as important messengers for intercellular communication within the musculoskeletal system, may be a new pathway and perspective for us to explore the pathogenesis, treatment targets, and crosstalk relationship between sarcopenia and osteoporosis. This article is based on the complex signaling effect of exosomes on various cells within the musculoskeletal system, and delves into the internal relationship between exosomes and musculoskeletal degenerative disease. It also looks forward to the application prospects of exosomes in the treatment of musculoskeletal degenerative disease.
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