Research Progress on the Role of Interleukin-10 in Maintaining Intestinal Homeostasis

TONG Le^1,2, LI Mei^1,3, TANG Xiaohan^1,3, HUANG Ling^1,3, ZHANG Changcheng^1,3, GUO Yuhui^1,3*

（¹Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang 443002, China; ²College of Basic Medical Science, China Three Gorges University, Yichang 443002, China; ³College of Medicine and Health Sciences, China Three Gorges University, Yichang 443002, China)

Abstract:

Intestinal homeostasis is a dynamic equilibrium state formed by the interaction of the host intestinal mucosa and immune barrier, intestinal environment, nutrients and metabolites. IL-10 (interleukin-10), a member of the IL-10 cytokine family, is an important anti-inflammatory cytokine in the immune response and plays an important role in maintaining intestinal homeostasis. This article reviewed the research progress of the role of Il-10 in maintaining intestinal homeostasis from four aspects: the maintenance of intestinal epithelial homeostasis, the integrity of intestinal barrier, the balance of gut microbiota and the anti-inflammatory effect in the intestine, the therapeutic prospect of IL-10 in intestinal diseases was prospected.

CSTR: 32200.14.cjcb.2023.09.0014