Effects of Cannabidiol on Ion Channels in Tumors
XIE Yanan, YU Dan, WAN Fang*
Cannabis sativa is an ancient medicinal plant commonly used to relieve pain and epileptic seizures. But the addictive nature of cannabinoids limits its clinical application. Cannabidiol, an extract of cannabis, is not psychoactive and has significantly less adverse reactions than Δ9-tetrahydrocannabinol, so it is widely favored. Ion channels are hydrophilic protein pores that run through the cell membrane, maintaining the body’s life activities, and they are also closely related to the occurrence and development of tumors. This article focuses on some transient receptor potential channels, voltage-dependent anion channel 1 and T type calcium channel affected by cannabidiol. Cannabidiol is a multi-target drug that is known to bind to ion channels, but its mechanism of action and binding sites are not clear. Although there are reviews on cannabidiol’s effect via ion channels, and on the relationship between ion channels and tumors, there is little literature summarizing the effect of cannabidiol via ion channels in tumors. This article mainly summarizes the possible ion channels bound by cannabidiol and their roles in tumor cells.
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