Progresses in the Research of Intestinal Stem Cells Markers
LI Mei, TONG Le, HUANG Ling, TANG Xiaohan, ZHANG Changcheng, GUO Yuhui*
In addition to self-renewal and pluripotency, ISCs (intestinal stem cells) also exhibit active proliferation, signaling activities, and special epigenetic and metabolic characteristics. The main role is to maintain the homeostasis of intestinal tissue, repair damaged intestinal mucosa and regulate intestinal cell differentiation. At present, there are two main types of ISCs, each of which has different specific markers and widely different biological functions, but they are closely related to the occurrence and development of intestinal diseases. Nevertheless, the lack of ISCs markers seriously limits the study of the biological characteristics of ISCs and hinders the clinical application of ISCs and its derivatives in the treatment of gut-related diseases. This article reviews the research progress of ISCs markers and intestinal iPSCs (induced pluripotent stem cells) in recent years, intend to provide useful clues for the clinical treatment of intestinal diseases.
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