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The Role of TRPV1 in Cerebral Ischemia and Its Complications
QIN Xuelian1,2, ZHANG Fan1,2, SHANG Wendou1,2, YAN Wenjing1,2, WANG Jinkun1,2, LIU Suya1,2, HE Zhi1,2*
( 1 Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; 2Basic Medical College, China Three Gorges University, Yichang 443002, China)
Abstract:
TRPV1 (transient receptor potential vanilloid subtype1) is known as capsaicin receptor, which a ligand-gated, non-selective calcium-permeable cation channels. The TRPV1 is widely distributed on the cell membrane of sensory neurons and other cells, and is involved in the regulation of various physiological functions after being activated, and plays a role in many diseases. In order to fully understand TRPV1, this article will review the mechanism, distribution, pathophysiological function of TRPV1, and mainly focus on the role of TRPV1 in cerebral ischemia and its complications
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