The Influence of the Interaction between Fasting Blood Glucose and piR-30715 on the Prognosis of Gastric Cancer Patients after Surgery

LIN Yunchai^1,2, HU Dan³, LIN Xiandong³, PENG Feng^1,2*

( ¹Department of Cardiology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, China; ² Department of Cardiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China; ³Department of Pathology of Fujian Cancer Hospital Affiliated to Fujian Medical University, Fuzhou 350014, China)

Abstract:

The paper aimed to study the effect of fasting blood glucose levels and piR-30715 (PIWI interacting RNA 30715) expression on the prognosis of gastric cancer. A total of 66 patients with gastric cancer underwent radical gastrectomy were enrolled from September 2014 to October 2016. The expression of piR-30715 and PIWIL4 (PIWI-like 4) in cancer tissues and adjacent tissues was analyzed. The Kaplan-Meier survival curve was used to analyze the relationship between fasting blood glucose, piR-30715, PIWIL4 and postoperative prognosis of gastric cancer patients. The COX regression was used to study the interaction between fasting blood glucose, piR-30715 and the prognosis of postoperative gastric cancer patients. Compared with adjacent tissues, the expression of piR-30715 and PIWIL4 in cancer tissue was significantly increased (P<0.05). As of December 31, 2020, 66 cases of gastric cancer were followed up for 1.25 to 75.73 months, with a median follow-up time of 57.05 months. Among 66 gastric cancer patients, 25 (37.88%) died and 41 (62.12%) survived. The univariate analysis showed that fasting blood glucose (OR=1.965, P<0.001), piR-30715 (OR=2.002, P=0.016), PIWIL4 positive (OR=2.683, P=0.018), TNM (tumor node metastasis) staging (OR=5.755, P=0.018), distant metastasis (OR=4.693, P=0.003) and lymph node metastasis (OR=3.654, P=0.036) were all associated with the prognosis of gastric cancer patients. The COX analysis showed that elevated fasting blood glucose and higher expression of piR-30715 were independent risk factors for the prognosis of gastric cancer (P<0.05). The survival analysis showed that the overall survival rate of gastric cancer patients in the higer fasting blood glucose group and higher expression of piR-30715 group was lower (P<0.05). There is a multiplicative interaction between fasting blood glucose and piR-30715 on the prognosis of gastric cancer (Pmultiplicative=0.003), but no additive interaction (P>0.05). Higher fasting blood glucose and higher expression of piR-30715 are independent risk factors for the prognosis of gastric cancer, and there is a multiplicative interaction between higher fasting blood glucose and higher expression of piR-30715 on the prognosis of gastric cancer.

CSTR: 32200.14.cjcb.2023.08.0004