Mechanism and Research Progress of miR-21 in Osteosarcoma

ZHANG Baolin¹, YANG Qinglin¹, WANG Mingchuan¹, SHANG Zhizhong¹, KE Yibing¹, WANG Xin^1,2*

(¹The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; ²Department of Orthopedics, the First Hospital of Lanzhou University, Lanzhou 730000, China)

Abstract:

OS (osteosarcoma) is a highly malignant primary tumor originating in bone tissue, predominating in children and adolescents. The occurrence and development mechanism of osteosarcoma is complex and the mortality rate and disability rate are high, which seriously impairs the health and quality of life of patients. Therefore, it is urgent to deeply study and elucidate the mechanism of osteosarcoma, and find early diagnostic markers and potential therapeutic targets with high specificity and sensitivity. Recent studies have shown that miR-21 is closely related to the occurrence and development of osteosarcoma. Therefore, this paper reviews the mechanism and progress of miR-21 in osteosarcoma, mainly miR-21 regulates the development of osteosarcoma by targeting related genes, regulating related signaling pathways (Wnt/β-catenin and PI3K/AKT signaling pathways) and by targeted binding of upstream signaling lncRNA and circRNA, aiming to provide references for the research on miR-21 and osteosarcoma and new strategies for the diagnosis and treatment of osteosarcoma.

CSTR: 32200.14.cjcb.2023.07.0016