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Research Progress of Eukaryotic Clamp Loading Complexes in DNA Damage Response and Repair
DUAN Jiaqi1, SUN Ruhao2, LIN Xiaodi2, ZHAO Jie2*, YU Luyang1*
(1School of Life Sciences, Zhejiang University, Hangzhou 310058, China; 2College of Life Sciences, State Key Laboratory of Hybrid Rice, Wuhan University, Wuhan 430072, China)
Abstract:
DDR (DNA damage response) is essential for organisms to maintain genomic accuracy and integrity. RFC (replication factor C) and its analogs RLCs (RFC-like clamp loaders) are sliding clamp loading complexes that play important roles in DNA damage repair in eukaryotes. In this paper, the research progress on the structural characteristics, biological functions and mechanisms of the four sliding clamp loading complexes in DNA damage repair were reviewed to provide comprehensive information and references for further exploring the mechanisms of DNA damage response and repair.
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