Recent Advances of PRMT5 in Breast Cancer
WANG Li1,2, ZHANG Jinghui1,2, WEI Haoliang1,2, LI Jingkai1,2, CUI Xuxin1,2, CHENG Fan1,2, YANG Xiaolai2*
PRMT5 (protein arginine methyltransferase 5) is a member of PRMTs (protein arginine methyltransferases) family and the primary type II methyltransferase that generates symmetric-dimethyl-arginine on both histone and non-histone proteins. PRMT5 is a potential oncogene, it has been implicated in the control of many cellular processes such as gene transcription, RNA splicing, DNA replication and DNA damage response. It is overexpressed in numerous human cancers, including breast cancer. Therefore, it has great prospect to be used as a new target for anti-breast cancer drug research. This paper reviews the recent advances of PRMT5 in breast cancer by consulting a large number of relevant literatures on PRMT5 and breast cancer, aiming to provide a reference for subsequent relevant research.
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