Research Progress on the Mechanism of Low Protein Diet to Improve Diabetic Kidney Disease
GUO Zongcheng, WANG Hao, MA Luyao, ZHANG Mingxuan, HE Enpeng*
In recent years, DKD (diabetic kidney disease) is one of the most common complications of diabetes and one of the important factors leading to ESKD (end-stage renal kidney disease). The main mechanism of DKD is the dysfunction of renal metabolism and hemodynamics caused by continuous hyperglycemia. As a nondrug treatment, low protein diet is of great significance for the intervention of DKD, CKD (chronic kidney disease) and other renal diseases. Therefore, this article will review the mechanism of action of low-protein diet intervention in DKD from five dimensions: islet β cells, glomerular filtration rate, mTOR (mammalian target of rapamycin) pathway, oxidative stress and intestinal flora.
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