Role of Non-Coding RNA in Spinal Cord Injury

YANG Qinglin¹, WANG Yikun¹, QIN Qingqing¹, LAN Zhijie¹, GUO Haoran¹, WANG Yongping^1,2*

(¹The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;²Department of Orthopedics, the First Hospital of Lanzhou University, Lanzhou 730000, China)

Abstract:

SCI (spinal cord injury) is a serious disease of the central nervous system, with a high disability rate and fatality rate, and its clinical symptoms depend on the location and severity of the lesion. At present, there is no effective treatment for spinal cord injury. Recent studies have confirmed that non-coding RNAs play an important regulatory role in the occurrence and development of spinal cord injury. This paper mainly reviews the classification and function of non-coding RNAs and the mechanism of action of non-coding RNAs in the pathogenesis of spinal cord injury, focusing on the mechanism of action of non-coding RNAs in the inflammatory response, mitochondrial dysfunction, oxidative stress, excitatory amino acid toxicity, angiogenesis, autophagy, apoptosis and other processes after spinal cord injury. This paper attempts to clarify the molecular mechanism of spinal cord injury and search for specific diagnostic markers and key therapeutic targets of spinal cord injury.

CSTR: 32200.14.cjcb.2023.06.0017