Research Progress on the Relationship between Interleukin-1 Family and Gout
GAO Lina1#, TAN Yuqing2#, YOU Chongge1*
IL-1 (interleukin-1) family has 11 members, and they participate in inflammatory processes as proinflammatory or anti-inflammatory cytokines. The most typical manifestation of gout is arthritis, and IL-1β is the core cytokine that causes gouty arthritis. However, recent studies have found that other members of the IL-1 family are also closely related to gout. IL-1 family not only play an important role in the initial stage of gout inflammation, but also participate in the inflammation persist and organ damage. IL-1 is also a judgment indicator of gout inflammation and a potential new target for gout treatment. This article reviews the relationship between IL-1 family cytokines and gout, in order to fully understand the relationship between IL-1 family and gout, and provide a basis for the prevention and treatment of gout.
CN
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