The Reactivity of Astrocytes and Its Role in Representative Neurological Diseases
ZHAO Qiancheng, GE Longjiao, ZHANG Runrui*
Astrocytes are the most abundant glial cells in the central nervous system, and they play important roles in the development, homeostasis and damage repair of the central nervous system. When the central nervous system suffers disease or trauma, the morphological and molecular characteristics of astrocytes at the site of injury are altered and transformed into reactive astrocytes. Reactive astrocytes are heterogeneous, with the most representative being the overview of the basic functions of astrocytes and the heterogeneity of reactive astrocytes, and delves into the role of reactive astrocytes in central nervous system diseases such as stroke, Alzheimer’s disease, Parkinson’s disease, and depression. This review aims to provide a theoretical basis for the development of new strategies for the treatment of neurological diseases using astrocytes.
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