Effects of CircRNA on Autophagy and Cancer Progression
ZHANG Xu, GUAN Yongyu, LIU Fang, CHEN Che*
CircRNA (circular RNA) is a non-coding RNA that has attracted much attention in recent years. circRNAs are highly stable in cells due to their unique closed-loop structure. Autophagy is a catabolic process that contributes to the degradation and recirculation of harmful or insignificant biomolecules in cells and enables cells to adapt to stresses and changes in the internal and external environments. There is evidence that circRNAs influence cancer progression by regulating autophagy, suggesting that autophagy is involved in the development and progression of various cancers and may influence drug resistance. The role of circRNAs in autophagy and its effects on tumorigenesis, progression and drug resistance were reviewed.
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