Research Progress on the Mechanism of Exercise Regulating JAK2/STAT Signaling Pathway to Treat the Non-Alcoholic Fatty Liver Disease
LIAO Chunwang1, HU Xuefeng2, LIU Zuhui1*
NAFLD (non-alcoholic fatty liver disease) is the most common type of chronic liver disease in modern society, including non-alcoholic simple fatty liver disease and non-alcoholic steatohepatitis, which are often complicated by other metabolic disorders and seriously affect human health. Exercise therapy is the most economical, convenient and effective way to prevent and treat NAFLD, and its mechanism involves the regulation of JAK2/ STAT signaling pathway, which is an important metabolism-related pathway. This paper discusses that exercise can directly or indirectly affect the JAK2/STAT signaling pathway by regulating the secretion levels of LEP, IGF-1 and GH in the body, which can enhance the level of lipid metabolism and improve NAFLD, in order to provide a reference for the mechanism of exercise intervention for NAFLD.
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