The Role of FOXO3 in Cerebral Ischemia

CHU Xiaojiao^1,2, WANG Jinkun^1,2, ZHANG Fan^1,2, SHANG Wendou^1,2, LIU Suya^1,2, HE Zhi^1,2*

(¹Third Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; ²Basic Medical Science, China Three Gorges University, Yichang 443002, China)

Abstract:

Cerebral ischemia is a major cause of death and long-term disability, which is a global health problem with complex etiology and unclear pathogenesis. The transcriptional factor FOXO3 (Forkhead box protein O3) changes its activity after PTMs (post-translation modifications), and it is involved in the regulation of apoptosis, inflammation, oxidative stress, autophagy and blood-brain barrier after cerebral ischemia through the regulations of target genes. It is noteworthy that FOXO3 not only promotes but also protects ischemic brain injury. In this paper, the structure and post-translational modification of FOXO3 are briefly introduced, and its role in cerebral ischemia is expounded, in order to provide new ideas for the study of this disease

CSTR: 32200.14.cjcb.2023.05.0012