Research Progress on the Role and Mechanism of Fas Ligand in Cervical Cancer Formation

FAN Xiaodong¹, ZHANG Binjie², HUA Yiwei¹, CHEN Shuaibo³, DONG Li³, LIU Xiaochun^2
*

( ¹School of Public Health, Shanxi Medical University, Taiyuan 030001, China; ² Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China; ³ Shanxi University Biomedical Research Institute, Taiyuan 030006, China)

Abstract:

FasL (Fas ligand) is a type II membrane protein that belongs to the tumor necrosis factor family and plays a certain physiological role in inducing apoptosis. Meanwhile, FasL is highly expressed in many tumor tissues and plays an important role in the development, metastasis and invasion of cervical cancer. The mechanism involves multiple signaling pathways, including participation in passive escape and active attack of tumor cells, maintenance of inflammation, and sending non-apoptotic signals to promote tumorigenesis. High FasL expression is associated with a poor tumor prognosis and a lower survival rate. Since FasL can be involved in tumor cell immune escape, targeted therapy against FasL may provide a new direction for cancer gene therapy or immunotherapy. This paper review the mechanism of FasL in cervical carcinogenesis and its application in the treatment of cervical cancer, so as to provide a scientific basis for exploring new therapeutic targets for cervical cancer.

CSTR: 32200.14.cjcb.2023.04.0014