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Regulation of Angiogenesis and Cell Function by Connective Tissue Growth Factor
Yun Yun, Hong-Feng Zhang*
School of Life Science, East China Normal University, Shanghai 200062, China
Abstract: Connective tissue growth factor (CTGF)， which has been investigated more， is a member of the CCN family of proteins. CTGF can promote cell growth， migration， adhesion and survival. It can also regulate the production and/or activity of other angiogenic molecules (e.g. bFGF， VEGF) as well molecules that affect the integrity or stability of the ECM (e.g. MMPs， TIMPs). CTGF can participate in a variety of direct and indirect mechanisms by which angiogenesis and cell function are regulated at multiple control points. Here， we elucidated the regulation of angiogenesis and cell function by CTGF and it's correlation with tumor growth combining with new discoveries and new insights.
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