Research Progress on the Role of the TRIM 9 in Diseases
MA Xiaomei1,2, SHU Xingfu1,2, CHEN Yao1,2, ZHAO Yu1,2, ZHANG Bowen1,2, MA Zhongren1, ZHANG Haixia1*
TRIM 9 is a brain-specific E3 ubiquitin ligase that works cooperatively with E2 ubiquitin-conjugating enzymes. Ubiquitin system is one of the post-translational modification modification systems. It is not only a marker of proteasome degradation target protein, but also a regulatory factor of protein interaction and enzyme activation. TRIM proteins play important roles in many physiological processes, including cell proliferation, apoptosis, DNA repair, signal transduction, innate immunity and carcinogenesis. At present, there are few studies on TRIM 9 protein, it is known that the abnormal expression of this protein in vivo is closely related to a variety of diseases, and its imbalance can lead to cancer, immune diseases or developmental disorders. This article mainly describes the role of TRIM 9 protein in clinical diseases and as one of the new biomarkers in clinical disease diagnosis, which lays a theoretical foundation for its indepth research in the clinical field.
CN
EN