Research Advances in Structure and Function of Complement C1q/Tumor Necrosis Factor-Related Protein 6

XIA Jingwen^1,2, LI Hanbing¹, WU Wenjing², YOU Zhongyu²*, ZHANG Jin²*

(¹College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; ²College of Biological Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314000, China)

Abstract:

CTRP6 (complement C1q/tumor necrosis factor-related protein 6) is an adipokine with high homology to adiponectin. It is widely expressed in various tissues of the human body. CTRP6 normally exerts its biological function in the form of a homotrimer. Studies have shown that CTRP6 plays an important regulatory role in various physiological and pathological processes such as lipid metabolism, obesity, diabetes, inflammation, tumor and fibrosis. In addition, CTRP6 also has certain application prospects in agricultural animal breeding. This article will provide a comprehensive review of the structural characteristics, expression regulation and main biological functions of CTRP6, which will provide references for further research of CTRP6.

CSTR: 32200.14.cjcb.2023.03.0019