Research Progress on the Role of Ion Channels in Repair of Central Nervous System Injury

ZHANG Susu¹, ZHAO Jiaxin¹, WU Man¹, ZHOU Yongxiu¹, WU Xuejuan¹, XIAO Jian¹*, WU Yanqing²*

(¹Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China; ²The Institute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University, Wenzhou 325035, China)

Abstract:

Nerve injury is a disease that caused by inflammation, trauma, stroke or other pathological factors. The main clinical manifestations of nerve injury are neuronal swelling and necrosis of the damaged site and insufficient blood supply of peripheral vascular. There are more and more studies confirmed that the ion channels are closely related to the nerve injury repair and functional degeneration. After injury, the production and release of nociceptive mediators regulate the transport activity of ion channels, and thus change neuronal excitability and neuronal function. This article will summarize the role of ion channels on nerve injury and repair, systematically elaborate the regulatory mechanism of ion channels in various diseases of central nerve injury, and provide a solid theoretical basis for further research on the molecular regulatory mechanism of nerve injury repair.

CSTR: 32200.14.cjcb.2023.03.0015