Home > Browse Issues > Vol.45 No.3
Function of HIV-1 Tat Protein in the Nucleus
LI Lu, NING Shuxiang, WANG Jihong*
(College of Life Science, Liaoning Normal University, Dalian 116081, China)
Abstract:
The HIV-1 Tat protein is an important regulator of HIV-1 viral gene expression and regulates cellular processes by interacting with different cellular molecules and signalling pathways. Tat protein is produced by infected cells and can also be secreted by infected cells to act on other cells; Therefore, it can affect both infected and uninfected cells. Tat protein accumulates in the nucleus, but depending on its different expression level, it may be localized in the nucleoplasm or nucleolus and exerts different nuclear effects. This article provides an overview of the structure, nuclear import mechanisms and nuclear effects of Tat proteins.
CN
EN