Molecular Regulation of Chromosomal Localization of Kinesin KIF4A
CHENG Beibei, YAN Luxia, HUANG Baihai, WANG Qiuyu, ZHU Changjun*
KIF4A is a kind of molecular motor that can hydrolyze ATP for energy using its own motor domain and move along microtubules towards its plus-end. KIF4A is also called chromokinesin because of its binding to chromosomes during cell division. KIF4A plays an important role in different phases of the cell cycle. During the interphase, KIF4A binds to chromatin and stabilizes chromatin structure. In early mitotic cells, KIF4A is involved in chromosome condensation, congression and alignment. By late mitosis, KIF4A is involved in the formation of central spindle, which regulates chromosome segregation and cytokinesis. The cytological function of KIF4A is determined by the correct localization of this molecular motor in each cell structure. Therefore, the various functions of KIF4A in regulating chromosomes rely on the localization of the molecular motor in the chromosome. Current studies have shown that many factors affect the localization of KIF4A on chromosomes. This article reviews the published factors controlling the localization of KIF4A on chromosomes and expounds the molecular mechanism regulating the localization of KIF4A on chromosomes, so as to provide new ideas for further research on the functional mechanism of KIF4A regulating chromosome.
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