Development and Treatment of Cancer from Abnormal Tricarboxylic Acid Cycle Metabolism

ZHOU Yuesi^1,2, QU Jialiang³, HAN Yinglun^1,2,4*

(¹College of Life Science, Liaoning Normal University, Dalian 116081, China; ²Lamprey Research Center, Liaoning Normal University, Dalian 116081, China; ³Production Technology Department, Vinyl Plant, Jilin Petrochemical Company, Jilin 132000, China; ⁴Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China)

Abstract:

Tricarboxylic acid cycle is the main way for aerobic organisms to obtain the energy needed for life activities. The synergistic action of multiple enzymes is required throughout the tricarboxylic acid cycle to produce a variety of intermediate metabolites as a way to maintain a stable environment for cell survival. Among the enzymes involved in the tricarboxylic acid cycle, when the activity of one or more of these enzymes changes, new metabolites are formed, thus changing the fate of the cell. This paper is based on the accumulation of a series of carcinogenic metabolites caused by the mutations of isocitrate dehydrogenase, succinate dehydrogenase and fumarase in the tricarboxylic acid cycle. The relationship between epigenetic changes caused by intermediate enzyme mutations in tricarboxylic acid cycle and tumorigenesis was reviewed in order to explore new ideas for cancer progress and treatment from the abnormal metabolism of tricarboxylic acid cycle.

CSTR: 32200.14.cjcb.2023.03.0010