Role of X-Box Binding Protein 1 in Cerebral Ischemia

YAN Wenjing^1,2, WU Fan^1,2, WANG Jinkun^1,2, ZHAO Hang^1,2, LI Yipeng^1,2, QIN Xuelian^1,2, HE Zhi^1,2*

(¹Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; ²Basic Medical College, China Three Gorges University, Yichang 443002, China)

Abstract:

XBP1 (X-box binding protein 1) is a basic leucine zipper structural protein, which plays an important role in the endoplasmic reticulum stress response after cerebral ischemia. XBP1 is expressed in the form of XBP1-u (X-box binding protein 1-unspliced) during non-ER (endoplasmic reticulum) stress, and in the form of XBP1-s (X-box binding protein 1-spliced) during ER stress. In order to fully understand XBP1, this article will review the structure, distribution, localization and pathophysiological functions of the two isomers of XBP1, and focus on the role of XBP1-s in activating the modification of oxo-N-acetylglucosamine, the expression of glucose regulatory protein-78 after cerebral ischemia to reduce oxidative stress damage, the injury of cerebral microvascular endothelial cells and cell apoptosis during cerebral ischemia.

CSTR: 32200.14.cjcb.2023.03.0009