Research Progress on the Mechanism of Comorbidity between Drug Addiction and Depression
LI Zonghui1,2, CAO Tong1,2, LU Yongli1,2, LI Zicheng1,2*
The comorbidity rate of drug addiction and depression is increasing gradually, and it has developed into a common mental comorbidity. But the relationship between the two diseases and the underlying mechanism are still unclear, and it is a major challenge to develop effective interventions for comorbidity of drug addiction with depression. A large amount of literatures shows that there are common brain regions and molecular mechanism underlying drug addiction with depression. In this review, the importance of brain regions such as the nucleus accumbens, the lateral habenula and the ventral tegmental area in this comorbidity is described. On the other hand, the role and mechanism of kappa opioid receptors, adrenocorticotropin-releasing factors and brain-derived neurotrophic factors in this comorbid disease are also described. These findings provide new ideas for the underlying mechanism of drug addiction comorbid depression, as well as new targets for the treatment of patients with drug addiction comorbid depression.
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