The Role of Long Non-Coding RNA in Regulating EMT and Tumor Invasion and Metastasis
WU Man1, LIU Yaping2*
EMT (epithelial-mesenchymal transition) is a biological process in which epithelial cells lose their polarity and tight cell connectivity under the action of certain factors and transform into migrating mesenchymal cells. EMT plays an important role in the invasion and metastasis of tumors. lncRNA (long non-coding RNA) is abnormally expressed in many cancers and plays an important role in the occurrence and development of tumors. lncRNA is also involved in tumor invasion and metastasis. In recent years, more and more studies have found that lncRNA participates in the regulation of EMT process, and then affects tumor invasion and metastasis, which has gradually become a potential target for clinical tumor diagnosis and treatment. This article will review the mechanism and clinical treatment of lncRNA in regulating EMT and tumor invasion and metastasis.
CN
EN