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Research Progress on the Structure and Function of Rab8
SUN Qian, KANG Bo*
(College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China)
Abstract:
Rab proteins are the largest subfamily of the small GTP-binding proteins. As a member of the Rab family, Rab8 continuously cycles between an inactive GDP-bound state and an active GTP-bound form. Different binding forms of Rab8 recruit different effectors to regulate the stages of vesicle formation, anchoring, and fusion. In addition, Rab8 is also involved in the regulation of autophagy and animal reproduction. This review summarizes the research progress of Rab8 in regulating vesicle transport, autophagy and animal reproductive function, in order to provide a reference for the follow-up study of Rab8 function.
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