Research Progress in the Structure, Function of Histone Demethylase KDM3B and Its Related Diseases

PENG Xiaoyan^1,2,3,4, YE Zhoujie^2,3,4, WANG Xinrui^2,3,4*

(¹Medical Research Center of Fujian Children’s Hospital, Fuzhou 350011, China; ²Medical Research Center of Fujian Maternal and Child Health Hospital, Fuzhou 350000, China; ³College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350000, China; ⁴NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-Human Primate (Fujian Maternity and Child Health Hospital), Fuzhou 350013, China)

Abstract:

Epigenetics is a genetic discipline that studies the gene expression changes caused by abnormalities in other mechanisms under the premise of unchanged DNA sequence. Histone methylation/demethylation modification, as a result of the dynamic interaction of methylase and demethylase, is one of the important regulatory mechanisms of epigenetics. The methylation and demethylation of H3K9 is one of the most thoroughly studied histone modifications in recent years. KDM3B contains JmjC domain and has inherent H3K9 demethylation activity. It can specifically remove H3K9me1/2 methylation modification, regulate gene transcription, DNA damage repair, and participate in cell proliferation, cell apoptosis, maintenance of stem cell stemness, occurrence and development of tumors and genetic diseases. This article reviews the structure, mechanism of action, biological function of histone demethylase KDM3B in the pathogenesis and development of disease, and it is expected to be a potential drug target for clinical research and treatment.

CSTR: 32200.14.cjcb.2023.03.0003