Research Progress of Heat Shock Protein 90 in Hepatocellular Carcinoma

In hepatocellular carcinoma, protein homeostasis is the basis of its growth and metastasis. Hsp90, as a molecular chaperone, maintains the stability of various cancer-promoting molecules and inhibits the activity of cancer-inhibiting molecules to maintain a balance between protein synthesis and degradation, so that cancer cells can still survive under the continuous stimulation of harsh microenvironment. However, severe adverse reactions to Hsp90 inhibitors in clinical trials resulted in none of the inhibitors being approved by the FDA. This paper describes the structure, expression regulation, chaperone circulation of Hsp90 and the relationship between Hsp90 overexpression and hepatocellular carcinoma, in order to clarify the role of Hsp90 in the occurrence and development of hepatocellular carcinoma and provide theoretical basis for clinical drug use

CSTR: 32200.14.cjcb.2023.03.0002