A Systematic Review on the Mechanism of PML Nuclear Body Assembly and Its Functions in Cancers and Pathogenic Infection

JIANG Yanling^{1, 2}, CHEN Li¹*, MENG Guoyu²*

(¹Kunming University of Science and Technology of Medicine, Kunming 650500, China; ²Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China)

Abstract:

PML (promyelocytic leukemia protein) was first discovered in patients with APL (acute promyelocytic leukemia). PML itself is a tumor suppressor protein and a core component of PML NBs (PML nuclear bodies). PML NBs can mediate various important cellular biological processes such as transcriptional regulation, protein modification, cell senescence and apoptosis. In the treatment of APL, targeted therapy for PML has been shown to be an effective treatment modality. A large number of studies have shown that PML proteins and PML nucleosomes not only play an important role in the pathogenesis and treatment of APL, but also play an important role in the occurrence, development and viral infection of various cancers. This article reviews the research breakthroughs in the field of PML in recent years, from the formation of PML, phase separation, post-translational modification to the role of PML in various cancers and viral infections, suggestive of more possibilities that PML can be used in cancer targeting and viral infection therapy.

CSTR: 32200.14.cjcb.2023.03.0001