Research Progress on the Roles and Mechanisms of Small Extracellular Vesicles Involved in Skin Diseases Including Photoaging
KONG Xiang1,2#, XU Kaiyan1,2#, WU Zhijing1,2#, WU Peipei1,2, HOU Xiaomei1,2, ZHANG Jiaxin1,2, LI Yu1,2, LI Jiali1,2, SUN Zixuan1,2*
sEVs (small extracellular vesicles) are new stars in the field of nanomedicine in recent years. They have unique morphological structures and physicochemical properties, which can act as mediators of intercellular information transmission and as biomarkers in the process of disease occurrence and development. Nowadays, people are paying more and more attention to the problem of skin photoaging, and the research on sEVs delaying and improving skin photoaging has gradually become a hot spot. sEVs derived from mesenchymal stem cells not only relieve inflammation and attenuate oxidative damage in skin photoaging, but also have significant effects on other skin diseases, such as skin trauma, plaque psoriasis, systemic erythema lupus and skin tumors. Furthermore, sEV is becoming a new drug delivery system due to its vesicular nature. However, when using stem cell-derived sEV as a new treatment method, it is still necessary to pay attention to its safety and toxicity.
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