CD36: Biological Functions, Mechanism of Action and ITs Associated Human Diseases

XIE Xiulong^1,2,3, NIU Zhenlan³, YANG Yi^1,2,3*

(¹Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; ²Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China; ³Beijing Biocytogen, Beijing 102609, China)

Abstract:

CD36 (cluster of differentiation 36) is a type 2 scavenger receptor widely expressed on the cell surface of a variety of immune and non-immune cells. CD36 binds to different ligands and mediates a variety of biological functions, thus participating in the pathological process of various diseases such as cancer, metabolic inflammatory syndrome and cardiovascular diseases. This review summarizes the gene CD36, CD36 protein structure and expression, and CD36 protein biological functions mediated by different ligands as well as recent findings that concern CD36, its ligands, its signaling properties, and its role in diseases, discuss the potential clinical applications of targeting the CD36 pathway for various diseases as previously mentioned. Furthermore, this review provides an overview of CD36 translational researches to promote the development of CD36 antibody drugs.

CSTR: 32200.14.cjcb.2023.02.0014