The Mechanism and Research Progress of miR-21 in Rheumatoid Arthritis

YANG Qinglin¹, KE Yibing¹, WANG Yikun¹, QIN Qingqing¹, XIE Ben¹, WANG Yongping^1,2*

(¹The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; ²Department of Orthopedics, the First Hospital of Lanzhou University, Lanzhou 730000, China)

Abstract:

RA (rheumatoid arthritis) is a chronic autoimmune disease of unknown etiology, which is characterized by multiple joints and symmetrical damage to the small joints of the hands and feet. The pathogenesis of RA is complex, the course of disease is long and the morbidity rate is relatively high, which seriously damages the health and quality of life of patients. miRNA is the most studied non-coding RNA in recent years, which plays an important role in the physiological and pathological processes of the body. Many studies have shown that miR-21 is closely related to the occurrence and development of RA. Therefore, this paper reviews the mechanism and progress of miR-21 in RA, miR-21 mainly through the interaction with lncRNA, targeting SNF5, TET1 and regulating related signaling pathways (Wnt, PI3K/AKT, JAK/STAT and NF-κB) to regulate RA, aiming to provide a reference for the related research of miR-21 and RA and provide a new strategy for the diagnosis and treatment of RA.

CSTR: 32200.14.cjcb.2023.02.0012