Progress in Proteasome and Aging
LUO Shiling1,2, YUAN Yuan1,2,3, LIU Xinguang1,2,3*
Proteasome consists of multiple subunit structures, which can clean up damaged or defective proteins, and maintain protein homeostasis. Proteasome system is the main pathway to control protein degradation. Multiple studies have shown that, the levels and activities of proteasome components gradually decrease with aging, which affect the occurrence and development of aging and age-related diseases, such as neurodegenerative diseases. At the same time, the decrease of proteasome activity will cause the imbalance of protein homeostasis and accelerate the senescence. This work presents an overview of recent research progress of proteasome in the field of aging, aiming to elucidate the relationship between proteasome and aging, which provides a theoretical basis for designing targeted drugs to prevent aging-related diseases or anti-aging.
CN
EN