Efficient Expansion Strategies of TILs Cells and Their Use in Clinical Treatment
DING Lan1, LI Guohao1, WANG Xin2, CHEN Qi1*, SHEN Yangkun1*
TILs (tumor-infiltrating lymphocytes) therapy can induce effective and durable clinical responses in most patients with metastatic cancer, revolutionizing ACT (adoptive cell therapy) in the treatment of solid tumors. The diverse TCR (T cell receptor) clonality, superior tumor homing ability, and low off-target toxicity give TILs a unique advantage over other ACTs in the treatment of solid tumors. However, obtaining sufficient clinical quantities of TILs requires complex cell processing and prolonged in vitro culture, which poses technical and regulatory challenges for the clinical application of TILs. To address this issue, the balance of efficient cell expansion and activity of TILs must be maintained during cell culture as a way to improve the effect of TILs in patients. In recent years, there have been numerous studies addressing various aspects of TILs, especially in the field of T cell proliferation and differentiation. This review will focus on the efficient expansion methods of TILs and the strategies of TILs in clinical treatment in recent years, either alone or in combination, in order to provide new insights into the efficient expansion and clinical application of TILs.
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