The Molecular Mechanism of AP Acinar Cell Injury Based on Gene Knockout Technique
WANG Qiong1 , WANG Zhandong1 , SONG Bing1,2, BAI Min1 , WANG Yongfeng1*, ZHANG Yanying1,2*, WEN Linlin1 , ZHAO Hongzhang1 , YANG Runze1
AP (acute pancreatitis) is a clinically multiple critical digestive system disease. Pancreatic acinar cell injury is one of the important pathological mechanisms of the occurrence and development of acute pancreatitis. Ca2+ overload, oxidative stress, autophagy damage, endoplasmic reticulum stress and other pathways are considered to be the key pathways of pancreatic acinar cell injury. However, the related mechanisms of specific genes, proteins and signaling pathways in this process are not completely clear. Gene knockout technology is the most effective method to reveal gene function and verify biological signal transduction pathway, which provides a new technical means to further clarify the molecular mechanism of pancreatic acinar cell injury in acute pancreatitis. This paper systematically reviewed the molecular mechanisms of acinar cell injury in AP based on gene knockout technology, in order to further clarify the pathophysiology of acinar cell injury in acute pancreatitis, promote the development of specific clinical drugs, improve the clinical efficacy of acute pancreatitis and improve the prognosis of patients.
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