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Mechanisms of Glucose Causing Mouse Embryo Damage by Chronic Oxidative Stress
Lei Zhang, Nan-Zhu Fang*, Jing-Chun Li
College of Agriculture, Yanbian University, Longjing 133400, China
Abstract: As one of important energy materials required for embryonic development, glucose in chorus excess causes embryo damage by reactive oxygen species (ROS), which are from multiple metabolizable pathways of glucose. Here, this review provide an overview of these mechanisms that glucose cause oxidation stress to mouse embryos, as well as a consideration of whether antioxidant strategies might be used to protect against further damage of embryonic development after high glucose.