Study on the Formation Mechanism and Application of Liver Organoids
BI Guoyun, ZHANG Haiyan*
Organoids, as a new “model organism”, can provide a new tool for the study of human development, disease occurrence and the screening of high-throughput drug due to their composition, structure and function are very similar to those of internal organs. Recent studies have shown that stem cells and liver parenchymal cells can form “liver organoids” under the synergistic action of specific extracellular matrix and various signaling molecules. Considering the urgent need of diagnosis and treatment of liver diseases, it is necessary to deeply understand the formation mechanism and application potential of liver organoids. This paper summarizes the current status of liver organoids research, which is of great significance for the rapid and efficient establishment of liver organoids with perfect structure and function in vitro and the study and treatment of liver diseases.
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