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High Osmolarity Glycerol MAP Kinase Signal Transduction Pathway
Hai-Hua Ruan, Xi-Chuan Li, Pei Lan, Ling-Huo Jiang*
College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China
Abstract: High osmolarity glycerol (HOG)， one of the classical MAP kinase cascades， is essential for cell survival under high osmolar conditions in Saccharomyces cerevisiae. Here， we reviewed the recent progress on the study of the whole HOG pathway as well as the regulation and functions of the components in the HOG pathway. The study on how yeast cells respond to high osmolarity has provided the basis for our understanding of mammalian and plant cells in response to environmental stresses.
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