Advances in Targeted Delivery Strategies for Central Nervous System Based on RVG Peptide

WANG He¹, SU Gang², CHAI Miao¹, DONG Ying¹, GAO Juan¹, LI Ruixin¹, ZHANG Zhenchang¹*

(Department of Neurology, Lanzhou University Second Hospital, Lanzhou 730030, China; ²Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China)

Abstract:

The BBB (blood-brain barrier) strictly regulates the substances flow of CNS (central nervous system), which is an important obstacle to CNS treatment. The polypeptide derived from the RVG (rabies virus glycoprotein) is highly neurotropic and can specifically bind to the nAChR (nicotinic acetylcholine receptors) in CNS, and then penetrate BBB through the RMT (receptor-mediated transcytosis) mechanism. The conjugated nucleic acids or proteins of RVG peptide are delivered to specific brain tissues or cells. RVG peptide can also combine with exosomes or nanoparticles, which are CNS drug delivery carriers, giving them CNS targeting properties. This article reviews the source and targeting mechanism of RVG peptide and its combination with exosomes and nanoparticles for CNS-targeted delivery, which provides a safe and non-invasive delivery strategy for CNS therap

CSTR: 32200.14.cjcb.2022.11.0016