Anti-Inflammatory Mechanisms of Vagus Nerve Stimulation in Epilepsy Treatment
ZHONG Qian1, QI Renli2, ZHAO Lu1, WEI Jingkuan1*
Epilepsy is a chronic neurological disorder caused by excessive excitation or abnormal synchronous discharge of neurons in the brain. It has the characteristics of recurrent, episodic and transient central nervous system dysfunction. Accumulating evidences show that excessive activation of inflammatory response plays an important role in the occurrence and development of epilepsy, and inflammatory signaling molecules have become a new target for antiepileptic therapy. VNS (vagus nerve stimulation) as an adjunctive therapy, can reduce seizures by combining with antiepileptic drugs. A large number of clinical applications have shown that VNS has high safety and effectiveness, but the mechanism of VNS is unclear. In recent years, studies have been carried out on the antiinflammatory mechanism of VNS in animal disease models and patients. In this paper, the potential immunomodulatory mechanism of VNS in peripheral and central system was reviewed.
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