The Role and Mechanism of SARM1 in the Nervous System

FAN Yiren^1,2, WU Qian², MIAO Xuemeng², PAN Xuyi², HU Lixin², MIAO Shuangda², LU Yi ², HUANG Zhihui^{1, 2}*

(¹School of Medicine, Hangzhou Normal University, Hangzhou 311121, China; ²School of Mental Health, Wenzhou Medical University, Wenzhou 325035, China)

Abstract:

SARM1 (sterile alpha and toll interleukin receptor motif-containing protein 1) is the latest adaptor that plays a role in TLR (Toll-like receptor) signal transmission. SARM1 is mainly expressed in the nervous system of mammals, which plays an essential role in the occurrence of neuroinflammation and neurodevelopment. SARM1 not only mediates the morphology and apoptosis of neurons, but also regulates the Waller degeneration of nerve fibers. What’s more, it also has an effect on the development of glial cells. Meanwhile, in the face of risk (infection, trauma, hypoxia, etc), SARM1, as the connection point between neuronal injury and innate immunity, provides a new starting point for the pathogenesis and treatment of neurodegenerative and psychiatric diseases. This article reviews the role and mechanism of SARM1 in the nervous system.

CSTR: 32200.14.cjcb.2022.11.0008