Research Progress on the Role of TGF-β and Smad Family in Keloid Formation
WANG Ruohan1, ZHANG Xiaopei1, SUN Jia1, SUN Zhenmin1, LI Yuli2, LI Yanyan2*
Keloid is a benign fibrous tumor of the skin caused by excessive proliferation of fibroblasts and excessive deposition of extracellular matrix in the dermis after skin injury. The pathogenesis is complex, which may be related to genetic, immune and cellular signal transduction pathways. Keloid is one of the frequently occurring diseases in clinic. Keloid scar can not only influence beauty, but also are often accompanied with picking pain, pruritus and even cause dysfunction. Due to the high recurrence rate after treatment, more and more researchers pay attention to the molecular mechanism of the keloid. Some studies have shown that TGF-β (transforming growth factor-β) is an important effective factor for the formation of keloid, which plays an important role in the regulation of cell proliferation, differentiation and immune function. In this paper, a correlative research on the relationship of TGF-β and Smad in keloid formation were summarized, and the pathogenesis of keloid was explored.
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